CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Putative activated CDC42 kinase 1

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q07912
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q07912
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q07912
ACK1_HUMAN
Homo sapiens
Activated CDC42 kinase 1

PDB Structure

PDB 4ID7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of potent, selective and orally bioavailable imidazo[1,5-a]pyrazine derived ACK1 inhibitors.
Jin, M., Wang, J., Kleinberg, A., Kadalbajoo, M., Siu, K.W., Cooke, A., Bittner, M.A., Yao, Y., Thelemann, A., Ji, Q., Bhagwat, S., Mulvihill, K.M., Rechka, J.A., Pachter, J.A., Crew, A.P., Epstein, D., Mulvihill, M.J.
Bioorg.Med.Chem.Lett.