CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Tyrosine-protein kinase receptor

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P06213
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P06213
INSR_HUMAN
Homo sapiens
Insulin receptor

PDB Structure

PDB 4IBM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A highly selective dual insulin receptor (IR)/insulin-like growth factor 1 receptor (IGF-1R) inhibitor derived from an extracellular signal-regulated kinase (ERK) inhibitor.
Anastassiadis, T., Duong-Ly, K.C., Deacon, S.W., Lafontant, A., Ma, H., Devarajan, K., Dunbrack, R.L., Wu, J., Peterson, J.R.
J.Biol.Chem.