CATH Classification

Domain Context

CATH Clusters

Superfamily Filoviridae VP35, C-terminal inhibitory domain, helical subdomain
Functional Family Polymerase cofactor VP35

Enzyme Information

UniProtKB Entries (1)

Q05127
VP35_EBOZM
Ebola virus - Mayinga, Zaire, 1976
Polymerase cofactor VP35

PDB Structure

PDB 4IBD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity.
Brown, C.S., Lee, M.S., Leung, D.W., Wang, T., Xu, W., Luthra, P., Anantpadma, M., Shabman, R.S., Melito, L.M., Macmillan, K.S., Borek, D.M., Otwinowski, Z., Ramanan, P., Stubbs, A.J., Peterson, D.S., Binning, J.M., Tonelli, M., Olson, M.A., Davey, R.A., Ready, J.M., Basler, C.F., Amarasinghe, G.K.
J.Mol.Biol.