CATH Classification

Domain Context

CATH Clusters

Superfamily 3.90.228.10
Functional Family Poly [ADP-ribose] polymerase tankyrase-2

Enzyme Information

2.4.2.30
NAD(+) ADP-ribosyltransferase.
based on mapping to UniProt O95271
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.
-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.
2.4.2.-
Pentosyltransferases.
based on mapping to UniProt O95271

UniProtKB Entries (1)

O95271
TNKS1_HUMAN
Homo sapiens
Poly [ADP-ribose] polymerase tankyrase-1

PDB Structure

PDB 4I9I
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of a class of novel tankyrase inhibitors that bind to both the nicotinamide pocket and the induced pocket.
Bregman, H., Gunaydin, H., Gu, Y., Schneider, S., Wilson, C., DiMauro, E.F., Huang, X.
J.Med.Chem.