CATH Domain 4i9hE02

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.110	L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
	3.90.110.10	Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal

Superfamily	Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family	L-lactate dehydrogenase A chain

1.1.1.27

L-lactate dehydrogenase.

based on mapping to UniProt P13491

(S)-lactate + NAD(+) = pyruvate + NADH.

-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

LDHA_RABIT

Oryctolagus cuniculus

L-lactate dehydrogenase A chain

PDB	4I9H
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors. Kohlmann, A., Zech, S.G., Li, F., Zhou, T., Squillace, R.M., Commodore, L., Greenfield, M.T., Lu, X., Miller, D.P., Huang, W.S., Qi, J., Thomas, R.M., Wang, Y., Zhang, S., Dodd, R., Liu, S., Xu, R., Xu, Y., Miret, J.J., Rivera, V., Clackson, T., Shakespeare, W.C., Zhu, X., Dalgarno, D.C. J.Med.Chem.