CATH Classification

Domain Context

CATH Clusters

Superfamily Pyruvate kinase, C-terminal domain
Functional Family

Enzyme Information

2.7.1.40
Pyruvate kinase.
based on mapping to UniProt P30615
ATP + pyruvate = ADP + phosphoenolpyruvate.
-!- UTP, GTP, CTP, ITP and dATP can also act as donors. -!- Also phosphorylates hydroxylamine and fluoride in the presence of CO(2).

UniProtKB Entries (1)

P30615
KPYK1_TRYBB
Trypanosoma brucei brucei
Pyruvate kinase 1

PDB Structure

PDB 4HYW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
`In crystallo' substrate binding triggers major domain movements and reveals magnesium as a co-activator of Trypanosoma brucei pyruvate kinase.
Zhong, W., Morgan, H.P., McNae, I.W., Michels, P.A., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Acta Crystallogr.,Sect.D