CATH Domain 4hyfB00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.228	Phosphoenolpyruvate Carboxykinase; domain 3
	3.90.228.10

Domain Context

CATH Clusters

Superfamily	3.90.228.10
Functional Family	Poly [ADP-ribose] polymerase tankyrase-2

Enzyme Information

2.4.2.-

Pentosyltransferases.

based on mapping to UniProt Q9H2K2

2.4.2.30

NAD(+) ADP-ribosyltransferase.

based on mapping to UniProt Q9H2K2

NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.

-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.

UniProtKB Entries (1)

Q9H2K2

TNKS2_HUMAN

Homo sapiens

Poly [ADP-ribose] polymerase tankyrase-2

PDB Structure

PDB	4HYF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Basis and SAR for G007-LK, a Lead Stage 1,2,4-Triazole Based Specific Tankyrase 1/2 Inhibitor. Voronkov, A., Holsworth, D.D., Waaler, J., Wilson, S.R., Ekblad, B., Perdreau-Dahl, H., Dinh, H., Drewes, G., Hopf, C., Morth, J.P., Krauss, S. J.Med.Chem.