CATH Classification

Domain Context

CATH Clusters

Superfamily Anticodon-binding domain
Functional Family bifunctional glutamate/proline--tRNA ligase

Enzyme Information

6.1.1.15
Proline--tRNA ligase.
based on mapping to UniProt P07814
ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).
6.1.1.17
Glutamate--tRNA ligase.
based on mapping to UniProt P07814
ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).

UniProtKB Entries (1)

P07814
SYEP_HUMAN
Homo sapiens
Bifunctional glutamate/proline--tRNA ligase

PDB Structure

PDB 4HVC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase.
Zhou, H., Sun, L., Yang, X.L., Schimmel, P.
Nature