CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha carbonic anhydrase
Functional Family Carbonic anhydrase 12

Enzyme Information

4.2.1.1
Carbonic anhydrase.
based on mapping to UniProt O43570
H(2)CO(3) = CO(2) + H(2)O.
-!- The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. -!- It is widespread and found in archaea, bacteria, and eukaryotes. -!- Three distinct classes exist, and appear to have evolved independently.

UniProtKB Entries (1)

O43570
CAH12_HUMAN
Homo sapiens
Carbonic anhydrase 12

PDB Structure

PDB 4HT2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
4-Substituted-2,3,5,6-tetrafluorobenzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, XII, and XIII.
Dudutiene, V., Zubriene, A., Smirnov, A., Gylyte, J., Timm, D., Manakova, E., Grazulis, S., Matulis, D.
Bioorg.Med.Chem.