1 keywords

CATH Domain 4hsgA01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.150 Vaccinia Virus protein VP39

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Protein arginine N-methyltransferase 3

Enzyme Information

2.1.1.-
Methyltransferases.
based on mapping to UniProt O60678

UniProtKB Entries (1)

O60678
ANM3_HUMAN
Homo sapiens
Protein arginine N-methyltransferase 3

PDB Structure

PDB 4HSG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors.
Liu, F., Li, F., Ma, A., Dobrovetsky, E., Dong, A., Gao, C., Korboukh, I., Liu, J., Smil, D., Brown, P.J., Frye, S.V., Arrowsmith, C.H., Schapira, M., Vedadi, M., Jin, J.
J. Med. Chem.