CATH Classification
Domain Context
CATH Clusters
| Superfamily | Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2 |
| Functional Family | Receptor protein-tyrosine kinase |
Enzyme Information
| 2.7.10.1 |
Receptor protein-tyrosine kinase.
based on mapping to UniProt P04626
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.
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UniProtKB Entries (1)
| P04626 |
ERBB2_HUMAN
Homo sapiens
Receptor tyrosine-protein kinase erbB-2
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PDB Structure
| PDB | 4HRN |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2.
Structure
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