CATH Classification

Domain Context

CATH Clusters

Superfamily Jelly Rolls
Functional Family

Enzyme Information

5.1.3.27
dTDP-4-dehydro-6-deoxy-D-glucose 3-epimerase.
based on mapping to UniProt Q5SFD1
dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D- allose.
-!- The enzyme is involved in the biosynthetic pathway of dTDP-6-deoxy- alpha-D-allose, which is converted to mycinose after attachment og the aglycones of several macrolide antibiotics, including tylosin, chalcomycin, dihydrochalcomycin, and mycinamicin II.

UniProtKB Entries (1)

Q5SFD1
CHMJ_STRBI
Streptomyces bikiniensis
DTDP-4-dehydro-6-deoxyglucose 3-epimerase

PDB Structure

PDB 4HMZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and Functional Studies on a 3'-Epimerase Involved in the Biosynthesis of dTDP-6-deoxy-d-allose.
Kubiak, R.L., Phillips, R.K., Zmudka, M.W., Ahn, M.R., Maka, E.M., Pyeatt, G.L., Roggensack, S.J., Holden, H.M.
Biochemistry