CATH Classification

Domain Context

CATH Clusters

Superfamily 6.10.140.550
Functional Family

Enzyme Information

3.1.3.16
Protein-serine/threonine phosphatase.
based on mapping to UniProt Q9NP77
[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.
-!- A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48). -!- The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).

UniProtKB Entries (1)

Q9NP77
SSU72_HUMAN
Homo sapiens
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

PDB Structure

PDB 4H3H
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72.
Xiang, K., Manley, J.L., Tong, L.
Genes Dev.