CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.429 | Macrophage Migration Inhibitory Factor |
|
3.30.429.10 | Macrophage Migration Inhibitory Factor |
Domain Context
CATH Clusters
| Superfamily | Macrophage Migration Inhibitory Factor |
| Functional Family | Macrophage migration inhibitory factor |
Enzyme Information
| 5.3.2.1 |
Phenylpyruvate tautomerase.
based on mapping to UniProt Q6DN04
Keto-phenylpyruvate = enol-phenylpyruvate.
-!- Also acts on other arylpyruvates.
|
| 5.3.3.12 |
L-dopachrome isomerase.
based on mapping to UniProt Q6DN04
L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.
-!- Stereospecific for L-dopachrome (5,6-dioxo-2,3-5,6-tetrahydroindole- 2-carboxylate). -!- Dopachrome methyl ester is a substrate, but dopaminochrome (2,3- dihydroxyindolyl-5,6-quinone) is not (see also EC 4.1.1.84).
|
UniProtKB Entries (1)
| Q6DN04 |
MIF_MACMU
Macaca mulatta
Macrophage migration inhibitory factor
|
PDB Structure
| PDB | 4GUM |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations.
Proc.Natl.Acad.Sci.USA
|