CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family focal adhesion kinase 1 isoform X2

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q05397
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q05397
FAK1_HUMAN
Homo sapiens
Focal adhesion kinase 1

PDB Structure

PDB 4GU9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Fragment-based discovery of new highly substituted 1H-pyrrolo[2,3-b]- and 3H-imidazolo[4,5-b]-pyridines as focal adhesion kinase inhibitors.
Heinrich, T., Seenisamy, J., Emmanuvel, L., Kulkarni, S.S., Bomke, J., Rohdich, F., Greiner, H., Esdar, C., Krier, M., Gradler, U., Musil, D.
J.Med.Chem.