CATH Classification

Domain Context

CATH Clusters

Superfamily Extracellular Endonuclease, subunit A
Functional Family ectonucleotide pyrophosphatase/phosphodiesterase family member 1

Enzyme Information

3.1.4.1
Phosphodiesterase I.
based on mapping to UniProt P06802
Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.
-!- Hydrolyzes both ribonucleotides and deoxyribonucleotides. -!- Has low activity toward polynucleotides. -!- A 3'-phosphate terminus on the substrate inhibits hydrolysis.
3.6.1.9
Nucleotide diphosphatase.
based on mapping to UniProt P06802
A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate.
-!- The enzyme preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates. -!- In vitro the enzyme also acts as a nucleotidohydrolase on ADP, NAD(+), NADP(+), FAD, and CoA. -!- Formerly EC 3.6.1.19.
3.1.4.39
Alkylglycerophosphoethanolamine phosphodiesterase.
based on mapping to UniProt Q9R1E6
1-alkyl-sn-glycero-3-phosphoethanolamine + H(2)O = 1-alkyl-sn-glycerol 3-phosphate + ethanolamine.
-!- Also acts on acyl and choline analogs.

UniProtKB Entries (1)

Q9R1E6
ENPP2_MOUSE
Mus musculus
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

PDB Structure

PDB 4GTZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling.
Kato, K., Nishimasu, H., Okudaira, S., Mihara, E., Ishitani, R., Takagi, J., Aoki, J., Nureki, O.
Proc.Natl.Acad.Sci.USA