CATH Classification

Domain Context

CATH Clusters

Superfamily Alkaline Phosphatase, subunit A
Functional Family Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

Enzyme Information
Phosphodiesterase I.
based on mapping to UniProt P06802
Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.
-!- Hydrolyzes both ribonucleotides and deoxyribonucleotides. -!- Has low activity toward polynucleotides. -!- A 3'-phosphate terminus on the substrate inhibits hydrolysis.
Nucleotide diphosphatase.
based on mapping to UniProt P06802
A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate.
-!- The enzyme preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates. -!- In vitro the enzyme also acts as a nucleotidohydrolase on ADP, NAD(+), NADP(+), FAD, and CoA. -!- Formerly EC
Alkylglycerophosphoethanolamine phosphodiesterase.
based on mapping to UniProt Q9R1E6
1-alkyl-sn-glycero-3-phosphoethanolamine + H(2)O = 1-alkyl-sn-glycerol 3-phosphate + ethanolamine.
-!- Also acts on acyl and choline analogs.

UniProtKB Entries (1)

Mus musculus
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

PDB Structure

External Links
Primary Citation
Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling.
Kato, K., Nishimasu, H., Okudaira, S., Mihara, E., Ishitani, R., Takagi, J., Aoki, J., Nureki, O.