CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Tyrosine-protein kinase receptor

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P04629
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P04629
NTRK1_HUMAN
Homo sapiens
High affinity nerve growth factor receptor

PDB Structure

PDB 4GT5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family.
Artim, S.C., Mendrola, J.M., Lemmon, M.A.
Biochem.J.