CATH Classification

Domain Context

CATH Clusters

Superfamily Glutaredoxin
Functional Family Glutathione S-transferase Mu

Enzyme Information

2.5.1.18
Glutathione transferase.
based on mapping to UniProt P04905
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.

UniProtKB Entries (1)

P04905
GSTM1_RAT
Rattus norvegicus
Glutathione S-transferase Mu 1

PDB Structure

PDB 4GST
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Snapshots along the reaction coordinate of an SNAr reaction catalyzed by glutathione transferase.
Ji, X., Armstrong, R.N., Gilliland, G.L.
Biochemistry