CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Site-specific DNA-methyltransferase (adenine-specific)

Enzyme Information

2.1.1.72
Site-specific DNA-methyltransferase (adenine-specific).
based on mapping to UniProt P0AEE8
S-adenosyl-L-methionine + adenine in DNA = S-adenosyl-L-homocysteine + N-6-methyladenine in DNA.
-!- This is a large group of enzymes, most of which form so-called 'restriction-modification systems', with nucleases that possess similar site specificity (the nucleases are listed as either EC 3.1.21.3, EC 3.1.21.4 and EC 3.1.21.5). -!- See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/

UniProtKB Entries (1)

P0AEE8
DMA_ECOLI
Escherichia coli K-12
DNA adenine methylase

PDB Structure

PDB 4GOO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis of Selective N-6 adenine methyltransferase Inhibition by Transition State Mimic
Harmer, J.E., McKelvie, J.C., Hobley, G., Roach, P.L.
To be published