CATH Classification

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family renin

Enzyme Information

3.4.23.15
Renin.
based on mapping to UniProt P00797
Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.
-!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.15 and EC 3.4.99.19.

UniProtKB Entries (1)

P00797
RENI_HUMAN
Homo sapiens
Renin

PDB Structure

PDB 4GJ6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Discovery of Novel Potent trans-3,4-Disubstituted Pyrrolidine Inhibitors of the Human Aspartic Protease Renin from in Silico Three-Dimensional (3D) Pharmacophore Searches.
Lorthiois, E., Breitenstein, W., Cumin, F., Ehrhardt, C., Francotte, E., Jacoby, E., Ostermann, N., Sellner, H., Kosaka, T., Webb, R.L., Rigel, D.F., Hassiepen, U., Richert, P., Wagner, T., Maibaum, J.
J.Med.Chem.