CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Tyrosine-protein kinase JAK2

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P29597
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P29597
TYK2_HUMAN
Homo sapiens
Non-receptor tyrosine-protein kinase TYK2

PDB Structure

PDB 4GII
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors.
Liang, J., van Abbema, A., Balazs, M., Barrett, K., Berezhkovsky, L., Blair, W., Chang, C., Delarosa, D., Devoss, J., Driscoll, J., Eigenbrot, C., Ghilardi, N., Gibbons, P., Halladay, J., Johnson, A., Kohli, P.B., Lai, Y., Liu, Y., Lyssikatos, J., Mantik, P., Menghrajani, K., Murray, J., Peng, I., Sambrone, A., Shia, S., Shin, Y., Smith, J., Sohn, S., Tsui, V., Ultsch, M., Wu, L.C., Xiao, Y., Yang, W., Young, J., Zhang, B., Zhu, B.Y., Magnuson, S.
J.Med.Chem.