CATH Classification

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family Beta-secretase 1

Enzyme Information

3.4.23.46
Memapsin 2.
based on mapping to UniProt P56817
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu- Phe in the Swedish variant of Alzheimer's amyloid precursor protein.
-!- Suggested to be the major 'beta-secretase' responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease. -!- Belongs to peptidase family A1.

UniProtKB Entries (1)

P56817
BACE1_HUMAN
Homo sapiens
Beta-secretase 1

PDB Structure

PDB 4GID
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-based design of highly selective beta-secretase inhibitors: synthesis, biological evaluation, and protein-ligand X-ray crystal structure.
Ghosh, A.K., Venkateswara Rao, K., Yadav, N.D., Anderson, D.D., Gavande, N., Huang, X., Terzyan, S., Tang, J.
J.Med.Chem.