CATH Classification

Domain Context

CATH Clusters

Superfamily Aspartate Aminotransferase, domain 1
Functional Family Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

Enzyme Information

2.6.1.7
Kynurenine--oxoglutarate transaminase.
based on mapping to UniProt Q8N5Z0
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
-!- Also acts on 3-hydroxykynurenine. -!- The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.
2.6.1.39
2-aminoadipate transaminase.
based on mapping to UniProt Q8N5Z0
L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate.

UniProtKB Entries (1)

Q8N5Z0
AADAT_HUMAN
Homo sapiens
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

PDB Structure

PDB 4GE4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions.
Tuttle, J.B., Anderson, M., Bechle, B.M., Campbell, B.M., Chang, C., Dounay, A.B., Evrard, E., Fonseca, K.R., Gan, X., Ghosh, S., Horner, W., James, L.C., Kim, J.Y., McAllister, L.A., Pandit, J., Parikh, V.D., Rago, B.J., Salafia, M.A., Strick, C.A., Zawadzke, L.E., Verhoest, P.R.
ACS Med Chem Lett