CATH Domain 4gb1A00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.120	6 Propeller
	2.120.10	Neuraminidase
	2.120.10.10

Domain Context

CATH Clusters

Superfamily	2.120.10.10
Functional Family

Enzyme Information

3.2.1.18

Exo-alpha-sialidase.

based on mapping to UniProt Q07599

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (1)

Q07599

NRAM_I63A3

Influenza A virus (A/duck/Ukraine/1/1963(H3N8))

Neuraminidase

PDB Structure

PDB	4GB1
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Synthesis and evaluation of novel 3-C-alkylated-Neu5Ac2en derivatives as probes of influenza virus sialidase 150-loop flexibility. Rudrawar, S., Kerry, P.S., Rameix-Welti, M.A., Maggioni, A., Dyason, J.C., Rose, F.J., van der Werf, S., Thomson, R.J., Naffakh, N., Russell, R.J., von Itzstein, M. Org.Biomol.Chem.