CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
Functional Family AMP phosphorylase

Enzyme Information

2.4.2.57
AMP phosphorylase.
based on mapping to UniProt Q5JCX3
(1) AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate. (2) CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate. (3) UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.
-!- The enzyme from archaea is involved in AMP metabolism and CO(2) fixation through type III RubisCO enzymes. -!- The activity with CMP and UMP requires activation by cAMP.

UniProtKB Entries (1)

Q5JCX3
AMPPA_THEKO
Thermococcus kodakarensis KOD1
AMP phosphorylase

PDB Structure

PDB 4GA5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure analysis of archaeal AMP phosphorylase reveals two unique modes of dimerization
Nishitani, Y., Aono, R., Nakamura, A., Sato, T., Atomi, H., Imanaka, T., Miki, K.
J.Mol.Biol.