CATH Classification

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family Collagenase 3

Enzyme Information

3.4.24.17
Stromelysin 1.
based on mapping to UniProt P08254
Preferential cleavage where P1', P2' and P3' are hydrophobic residues.
-!- Extracellular endopeptidase of vertebrate tissues. -!- Degradation of proteoglycans, fibronectin, collagen type III, IV, V and IX and activates procollagenase. -!- Belongs to peptidase family M10B.

UniProtKB Entries (1)

P08254
MMP3_HUMAN
Homo sapiens
Stromelysin-1

PDB Structure

PDB 4G9L
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of matrix metalloproteinase-3 with a platinum-based inhibitor.
Belviso, B.D., Caliandro, R., Siliqi, D., Calderone, V., Arnesano, F., Natile, G.
Chem.Commun.(Camb.)