CATH Classification

Domain Context

CATH Clusters

Superfamily HAD superfamily/HAD-like
Functional Family Beta-phosphoglucomutase

Enzyme Information

5.4.2.6
Beta-phosphoglucomutase.
based on mapping to UniProt P77366
Beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate.
-!- The enzyme is able to autophosphorylate itself with its substrate beta-D-glucose 1-phosphate. -!- Although this is a slow reaction, only a single turnover is required for activation. -!- Once the phosphorylated enzyme is formed, it generates the reaction intermediate beta-D-glucose 1,6-bisphosphate, which can be used to phosphorylate the enzyme in subsequent cycles. -!- Cf. EC 5.4.2.2.

UniProtKB Entries (1)

P77366
PGMB_ECOLI
Escherichia coli K-12
Beta-phosphoglucomutase

PDB Structure

PDB 4G9B
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of beta-phosphoglucomutase homolog from escherichia coli, target efi-501172, with bound mg, open lid
Vetting, M.W., Toro, R., Bhosle, R., Al Obaidi, N.F., Morisco, L.L., Wasserman, S.R., Sojitra, S., Washington, E., Scott Glenn, A., Chowdhury, S., Evans, B., Hammonds, J., Hillerich, B., Love, J., Seidel, R.D., Imker, H.J., Dunaway-Mariano, D., Allen, K.N., Gerlt, J.A., Almo, S.C., Enzyme Function Initiative (EFI)
To be Published