CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.1120.120
Functional Family serine/threonine-protein kinase PLK4 isoform X2

Enzyme Information

2.7.11.21
Polo kinase.
based on mapping to UniProt O97143
ATP + a protein = ADP + a phosphoprotein.
-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

O97143
PLK4_DROME
Drosophila melanogaster
Serine/threonine-protein kinase PLK4

PDB Structure

PDB 4G7N
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The structure of the plk4 cryptic polo box reveals two tandem polo boxes required for centriole duplication.
Slevin, L.K., Nye, J., Pinkerton, D.C., Buster, D.W., Rogers, G.C., Slep, K.C.
Structure