CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Mitogen-activated protein kinase kinase kinase 14

Enzyme Information

2.7.11.25
Mitogen-activated protein kinase kinase kinase.
based on mapping to UniProt Q9WUL6
ATP + a protein = ADP + a phosphoprotein.
-!- This enzyme phosphorylates and activates its downstream protein kinase, EC 2.7.12.2, but requires MAPKKKK for activation. -!- Some members of this family can be activated by p21-activated kinases (PAK/STE20) or Ras. -!- While c-Raf and c-Mos activate the classical MAPK/ERK pathway, MEKK1 and MEKK2 preferentially activate the c-Jun N-terminal protein kinase(JNK)/stress-activated protein kinase (SAPK) pathway. -!- Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. -!- Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q9WUL6
M3K14_MOUSE
Mus musculus
Mitogen-activated protein kinase kinase kinase 14

PDB Structure

PDB 4G3E
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site.
de Leon-Boenig, G., Bowman, K.K., Feng, J.A., Crawford, T., Everett, C., Franke, Y., Oh, A., Stanley, M., Staben, S.T., Starovasnik, M.A., Wallweber, H.J., Wu, J., Wu, L.C., Johnson, A.R., Hymowitz, S.G.
Structure