CATH Classification

Domain Context

CATH Clusters

Superfamily 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family Phosphodiesterase

Enzyme Information

3.1.4.35
3',5'-cyclic-GMP phosphodiesterase.
based on mapping to UniProt O76074
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

UniProtKB Entries (1)

O76074
PDE5A_HUMAN
Homo sapiens
CGMP-specific 3',5'-cyclic phosphodiesterase

PDB Structure

PDB 4G2W
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5.
Wang, G., Liu, Z., Chen, T.T., Wang, Z., Yang, H., Zheng, M., Ren, J., Tian, G., Yang, X., Li, L., Li, J., Suo, J., Zhang, R., Jiang, X., Terrett, N.K., Shen, J., Xu, Y.C., Jiang, H.
J.Med.Chem.