CATH Classification

Domain Context

CATH Clusters

Superfamily 2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family Putative enoyl-CoA hydratase PaaB

Enzyme Information

5.3.3.18
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase.
based on mapping to UniProt P77467
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA = 2-oxepin-2(3H)-ylideneacetyl- CoA.
-!- The enzyme catalyzes the reversible isomerization of 2-(1,2-epoxy- 1,2-dihydrophenyl)acetyl-CoA to the unusual unsaturated, oxygen- containing, seven-member heterocyclic enol ether 2-oxepin-2(3H)- ylideneacetyl-CoA, as part of an aerobic phenylacetate degradation pathway.

UniProtKB Entries (1)

P77467
PAAG_ECOLI
Escherichia coli K-12
1,2-epoxyphenylacetyl-CoA isomerase

PDB Structure

PDB 4FZW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Protein-Protein Interactions in the beta-Oxidation Part of the Phenylacetate Utilization Pathway. Crystal Structure of the PaaF-PaaG Hydratase-Isomerase Complex
Grishin, A.M., Ajamian, E., Zhang, L., Rouiller, I., Bostina, M., Cygler, M.
J.Biol.Chem.