CATH Classification

Domain Context

CATH Clusters

Superfamily 2.120.10.10
Functional Family Hemagglutinin-neuraminidase

Enzyme Information

3.2.1.18
Exo-alpha-sialidase.
based on mapping to UniProt P12558
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (1)

P12558
HN_NDVU
Newcastle disease virus Ulster/67
Hemagglutinin-neuraminidase

PDB Structure

PDB 4FZH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the ulster strain newcastle disease virus hemagglutinin-neuraminidase reveals auto-inhibitory interactions associated with low virulence.
Yuan, P., Paterson, R.G., Leser, G.P., Lamb, R.A., Jardetzky, T.S.
Plos Pathog.