CATH Classification

Domain Context

CATH Clusters

Superfamily 1.25.50.20
Functional Family Aminopeptidase N

Enzyme Information

3.4.11.2
Membrane alanyl aminopeptidase.
based on mapping to UniProt P15144
Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.
-!- Is not activated by heavy metal ions. -!- Belongs to peptidase family M1. -!- Formerly EC 3.4.1.2, EC 3.4.3.5 and EC 3.4.13.6.

UniProtKB Entries (1)

P15144
AMPN_HUMAN
Homo sapiens
Aminopeptidase N

PDB Structure

PDB 4FYT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The X-ray Crystal Structure of Human Aminopeptidase N Reveals a Novel Dimer and the Basis for Peptide Processing.
Wong, A.H., Zhou, D., Rini, J.M.
J.Biol.Chem.