CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Tyrosine-protein kinase SYK

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P43405
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P43405
KSYK_HUMAN
Homo sapiens
Tyrosine-protein kinase SYK

PDB Structure

PDB 4FYO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Rational design of highly selective spleen tyrosine kinase inhibitors.
Lucas, M.C., Goldstein, D.M., Hermann, J.C., Kuglstatter, A., Liu, W., Luk, K.C., Padilla, F., Slade, M., Villasenor, A.G., Wanner, J., Xie, W., Zhang, X., Liao, C.
J.Med.Chem.