CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.450.330
Functional Family Peptidoglycan D,D-transpeptidase FtsI

Enzyme Information

3.4.16.4
Serine-type D-Ala-D-Ala carboxypeptidase.
based on mapping to UniProt Q51504
Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.
-!- A group of bacterial enzymes, membrane-bound. -!- Inhibited by beta-lactam antibiotics, which acylate the active site serine in the enzyme. -!- Distinct from EC 3.4.17.14. -!- Belongs to peptidase families S11, S12 and S13.

UniProtKB Entries (1)

Q51504
Q51504_PSEAI
Pseudomonas aeruginosa
Peptidoglycan D,D-transpeptidase FtsI

PDB Structure

PDB 4FSF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections.
Mitton-Fry, M.J., Arcari, J.T., Brown, M.F., Casavant, J.M., Finegan, S.M., Flanagan, M.E., Gao, H., George, D.M., Gerstenberger, B.S., Han, S., Hardink, J.R., Harris, T.M., Hoang, T., Huband, M.D., Irvine, R., Lall, M.S., Megan Lemmon, M., Li, C., Lin, J., McCurdy, S.P., Mueller, J.P., Mullins, L., Niosi, M., Noe, M.C., Pattavina, D., Penzien, J., Plummer, M.S., Risley, H., Schuff, B.P., Shanmugasundaram, V., Starr, J.T., Sun, J., Winton, J., Young, J.A.
Bioorg.Med.Chem.Lett.