CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.1050.10
Functional Family

Enzyme Information

1.8.5.7
Glutathionyl-hydroquinone reductase.
based on mapping to UniProt Q8KN33
Glutathione + 2-(glutathione-S-yl)-hydroquinone = glutathione disulfide + hydroquinone.
-!- This type of enzymes, which are found in bacteria, halobacteria, fungi, and plants, catalyze the glutathione-dependent reduction of glutathionyl-hydroquinones. -!- The enzyme from the bacterium Sphingobium chlorophenolicum can act on halogenated substrates such as 2,6-dichloro-3-(glutathione-S-yl)- hydroquinone and 2,3,5-trichloro-6-(glutathione-S-yl)-hydroquinone. -!- Substrates for these enzymes are often formed spontaneously by interaction of benzoquinones with glutathione.

UniProtKB Entries (1)

Q8KN33
PCPF_SPHCR
Sphingobium chlorophenolicum
Glutathionyl-hydroquinone reductase PcpF

PDB Structure

PDB 4FQU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural understanding of the glutathione-dependent reduction mechanism of glutathionyl-hydroquinone reductases.
Green, A.R., Hayes, R.P., Xun, L., Kang, C.
J.Biol.Chem.