CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.70.100
Functional Family

Enzyme Information

1.14.99.48
Heme oxygenase (staphylobilin-producing).
based on mapping to UniProt Q7A827
(1) Protoheme + 5 reduced acceptor + 4 O(2) = 5-oxo-delta-bilirubin + Fe(2+) + formaldehyde + 5 acceptor + 4 H(2)O. (2) Protoheme + 5 reduced acceptor + 4 O(2) = 15-oxo-beta-bilirubin + Fe(2+) + formaldehyde + 5 acceptor + 4 H(2)O.
-!- This enzyme, which is found in some pathogenic bacteria, is involved in an iron acquisition system that catabolizes the host's hemoglobin. -!- The two enzymes from the bacterium Staphylococcus aureus, encoded by the isdG and isdI genes, produce 67.5 % and 56.2 % delta- staphylobilin, respectively.

UniProtKB Entries (1)

Q7A827
HDOX2_STAAN
Staphylococcus aureus subsp. aureus N315
Heme oxygenase (staphylobilin-producing) 2

PDB Structure

PDB 4FNH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inactivation of the heme degrading enzyme IsdI by an active site substitution that diminishes heme ruffling.
Ukpabi, G., Takayama, S.J., Mauk, A.G., Murphy, M.E.
J.Biol.Chem.