CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.60.20
Functional Family Protein kinase C delta

Enzyme Information

2.7.11.13
Protein kinase C.
based on mapping to UniProt Q02111
ATP + a protein = ADP + a phosphoprotein.
-!- A family of serine- and threonine-specific protein kinases that depend on lipids for activity. -!- They can be activated by calcium but have a requirement for the second messenger diacylglycerol. -!- Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways. -!- Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q02111
KPCT_MOUSE
Mus musculus
Protein kinase C theta type

PDB Structure

PDB 4FKD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Identification of the Activator Binding Residues in the Second Cysteine-Rich Regulatory Domain of Protein Kinase C Theta.
Rahman, G.M., Shanker, S., Lewin, N.E., Kedei, N., Hill, C.S., Prasad, B.V., Blumberg, P.M., Das, J.
Biochem.J.