CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4
Functional Family Phosphatidylinositol 3-kinase gamma isoform

Enzyme Information
Phosphatidylinositol-4,5-bisphosphate 3-kinase.
based on mapping to UniProt P48736
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P48736
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC and EC

UniProtKB Entries (1)

Homo sapiens
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

PDB Structure

External Links
Primary Citation
Discovery and in Vivo Evaluation of Dual PI3K-beta/delta inhibitors
Gonzalez-Lopez de Turiso, F., Shin, Y., Brown, M., Cardozo, M., Chen, Y., Fong, D., Hao, X., He, X., Henne, K., Hu, Y.L., Johnson, M.G., Kohn, T., Lohman, J., McBride, H.J., McGee, L.R., Medina, J.C., Metz, D., Miner, K., Mohn, D., Pattaropong, V., Seganish, J., Simard, J.L., Wannberg, S., Whittington, D.A., Yu, G., Cushing, T.D.