CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrofolate Reductase, subunit A
Functional Family Dihydrofolate reductase

Enzyme Information

1.5.1.3
Dihydrofolate reductase.
based on mapping to UniProt P0ABQ4
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

UniProtKB Entries (1)

P0ABQ4
DYR_ECOLI
Escherichia coli K-12
Dihydrofolate reductase

PDB Structure

PDB 4FHB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Oyen, D., Wechselberger, R., Srinivasan, V., Steyaert, J., Barlow, J.N.
Biochim.Biophys.Acta