CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.1460
Functional Family Legumain

Enzyme Information

3.4.22.34
Legumain.
based on mapping to UniProt Q99538
Hydrolysis of proteins and small molecule substrates at -Asn-|- Xaa- bonds.
-!- Best known from legume seeds, the trematode Schistosoma mansoni and mammalian lysosomes. -!- Not inhibited by compound E-64. -!- Belongs to peptidase family C13.

UniProtKB Entries (1)

Q99538
LGMN_HUMAN
Homo sapiens
Legumain

PDB Structure

PDB 4FGU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation.
Dall, E., Brandstetter, H.
Proc.Natl.Acad.Sci.USA