CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside phosphorylase domain
Functional Family Aminodeoxyfutalosine nucleosidase

Enzyme Information

3.2.2.9
Adenosylhomocysteine nucleosidase.
based on mapping to UniProt Q9ZMY2
S-adenosyl-L-homocysteine + H(2)O = S-(5-deoxy-D-ribos-5-yl)-L- homocysteine + adenine.
3.2.2.30
Aminodeoxyfutalosine nucleosidase.
based on mapping to UniProt Q9ZMY2
6-amino-6-deoxyfutalosine + H(2)O = dehypoxanthine futalosine + adenine.
-!- The enzyme, found in several bacterial species, catalyzes a step in a modified futalosine pathway for menaquinone biosynthesis. -!- While the enzyme from some organisms also has the activity of EC 3.2.2.9 the enzyme from Chlamydia trachomatis is specific for 6-amino-6-deoxyfutalosine.

UniProtKB Entries (1)

Q9ZMY2
MQMTN_HELPJ
Helicobacter pylori J99
Aminodeoxyfutalosine nucleosidase

PDB Structure

PDB 4FFS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A Picomolar Transition State Analogue Inhibitor of MTAN as a Specific Antibiotic for Helicobacter pylori.
Wang, S., Haapalainen, A.M., Yan, F., Du, Q., Tyler, P.C., Evans, G.B., Rinaldo-Matthis, A., Brown, R.L., Norris, G.E., Almo, S.C., Schramm, V.L.
Biochemistry