CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P0AD64
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P0AD64
BLA1_KLEPN
Klebsiella pneumoniae
Beta-lactamase SHV-1

PDB Structure

PDB 4FD8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of a pre-acylation complex of the beta-lactamase inhibitor, sulbactam, bound to a sulfenamide bond containing thiol-beta-lactamase
Rodkey, E.A., Drawz, S.M., Sampson, J.M., Bethel, C.R., Bonomo, R.A., van den Akker, F.
J.Am.Chem.Soc.