CATH Classification

Domain Context

CATH Clusters

Superfamily Histidine kinase-like ATPase, C-terminal domain
Functional Family Heat shock protein HSP 90-alpha

Enzyme Information

UniProtKB Entries (1)

P07900
HS90A_HUMAN
Homo sapiens
Heat shock protein HSP 90-alpha

PDB Structure

PDB 4FCQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.
Davies, N.G., Browne, H., Davis, B., Drysdale, M.J., Foloppe, N., Geoffrey, S., Gibbons, B., Hart, T., Hubbard, R., Jensen, M.R., Mansell, H., Massey, A., Matassova, N., Moore, J.D., Murray, J., Pratt, R., Ray, S., Robertson, A., Roughley, S.D., Schoepfer, J., Scriven, K., Simmonite, H., Stokes, S., Surgenor, A., Webb, P., Wood, M., Wright, L., Brough, P.
Bioorg.Med.Chem.