CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.450.50
Functional Family Ras GTPase-activating protein-binding protein 2 isoform 1

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt Q13283
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).
3.6.4.13
RNA helicase.
based on mapping to UniProt Q13283
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

Q13283
G3BP1_HUMAN
Homo sapiens
Ras GTPase-activating protein-binding protein 1

PDB Structure

PDB 4FCJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of the Human G3BP1 NTF2-Like Domain Visualize FxFG Nup Repeat Specificity.
Vognsen, T., Moller, I.R., Kristensen, O.
Plos One