CATH Classification

Domain Context

CATH Clusters

Superfamily Ricin (A subunit), domain 1
Functional Family

Enzyme Information

3.2.2.22
rRNA N-glycosylase.
based on mapping to UniProt P22244
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P22244
RIP1_HORVU
Hordeum vulgare
Protein synthesis inhibitor I

PDB Structure

PDB 4FBC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of the ribosome-inactivating protein from barley seeds reveal a unique activation mechanism.
Lee, B.G., Kim, M.K., Kim, B.W., Suh, S.W., Song, H.K.
Acta Crystallogr.,Sect.D