CATH Classification

Domain Context

CATH Clusters

Superfamily FKBP12-rapamycin binding domain
Functional Family Probable Serine/threonine-protein kinase TOR2

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P42345
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P42345
MTOR_HUMAN
Homo sapiens
Serine/threonine-protein kinase mTOR

PDB Structure

PDB 4FAP
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.
Liang, J., Choi, J., Clardy, J.
Acta Crystallogr.,Sect.D