CATH Classification

Domain Context

CATH Clusters

Superfamily C2 domain
Functional Family RNA helicase, activating signal cointegrator 1

Enzyme Information

3.6.4.13
RNA helicase.
based on mapping to UniProt O75643
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

O75643
U520_HUMAN
Homo sapiens
U5 small nuclear ribonucleoprotein 200 kDa helicase

PDB Structure

PDB 4F93
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome.
Santos, K.F., Jovin, S.M., Weber, G., Pena, V., Luhrmann, R., Wahl, M.C.
Proc.Natl.Acad.Sci.USA