CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Geranyl diphosphate 2-C-methyltransferase

Enzyme Information

2.1.1.255
Geranyl diphosphate 2-C-methyltransferase.
based on mapping to UniProt D3KYU3
S-adenosyl-L-methionine + geranyl diphosphate = S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate.
-!- This enzyme, along with EC 4.2.3.118, produces 2-methylisoborneol, an odiferous compound produced by soil microorganisms with a strong earthy/musty odor. -!- Formerly EC 2.1.1.n6.

UniProtKB Entries (1)

D3KYU3
GPPMT_STRLS
Streptomyces lasaliensis
Geranyl diphosphate 2-C-methyltransferase

PDB Structure

PDB 4F86
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure analysis of geranyl pyrophosphate methyltransferase and the proposed reaction mechanism of SAM-dependent C-methylation
Ariyawutthiphan, O., Ose, T., Minami, A., Sinde, S., Tsuda, M., Gao, Y.-G., Yao, M., Oikawa, H., Tanaka, I.
Acta Crystallogr.,Sect.D